Thiazolidinediones - a new class of drugs that have proven effectiveness in the treatment of diabetes type 2. These drugs increase insulin sensitivity.
The first remedy from this group, registered for the treatment of patients with diabetes type 2 as a single agent and in combination with oral antidiabetic drugs or insulin, is pioglitazone hydrochloride – generic Actos.
Like other members of this class of drugs, Actos does not increase the effect on insulin secretion from beta cells of the pancreas. This leads to improved glycemic control in patients with diabetes type 2 at low risk of hypoglycemia. In addition to lowering blood glucose, improved insulin sensitivity of tissues to a favorable effect on lipid profile (raising HDL, lowering triglycerides).
Doctors recommend patients with diabetes mellitus type 2 to buy Actos: 1. As an adjunct to diet and exercise; 2. To carry out alone or in combination therapy with sulfonylurea derivatives, metformin, or insulin in case of failure of diet, exercise and assignment alone one of the above drugs.
Numerous clinical studies, made around the world, have proved the efficacy and safety of Actos in patients with diabetes mellitus type 2. Actos without prescription has good hypoglycemic effect as monotherapy in patients with type 2 diabetes and obesity. Against the background of the 12 weeks therapy with Actos 70% of patients had achieved a good compensation of diabetes, 30% of patients achieved ideal glycemic control.
Actos significantly reduces insulin resistance, improving insulin sensitivity of peripheral tissues and liver (observed decrease in HOMA-IR by 48%). Application of Actos has a positive effect on the lipid profile of patients with type 2 diabetes. VLDL was significantly reduced by 26%, TC by 12%, TG by 33%.
Actos doesn’t cause weight gain, however, noted the positive effect of Actos in visceral obesity. Cheap Actos is used in monotherapy and well tolerated and safe hypoglycemic agent.
Actos drugs are highly effective and well tolerated, not only in young, but also in elderly patients with diabetes mellitus type 2 (65 years). Food intake and gastric acidity does not affect the absorption of Actos in the gastrointestinal tract.
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